Top Page | English | 简体中文 | 繁體中文 | 한국어 | 日本語
Wednesday, 20 June 2018, 10:00 HKT/SGT
Share:
    

Source: Pertanika Journal
Blood vessel-forming cells involved in aggressive brain tumour
Targeting cells involved in blood vessel formation could prevent the growth of the most common type of brain tumour.

Selangor, Malaysia, June 20, 2018 - (ACN Newswire) - A type of highly malignant brain tumour contains a large number of cells involved in the formation of new blood vessels, helping it proliferate and spread. Targeting these cells could hinder tumour growth, according to new research published in the Pertanika Journal of Science & Technology.

Astrocytomas are tumours that can be found in the brain and spinal cord and originate from a type of cell, called an astrocyte, whose main function is to insulate and to provide structure for nerve fibres. They are the most common type of tumour that originates in the brain. There are four grades of astrocytomas, ranging from least to most aggressive. Grade IV astrocytomas are highly invasive and are almost always fatal. Lower grade astrocytomas are typically found in younger people while higher grade tumours are more often found in older adults.

Astrocytomas depend on new blood vessel formation to grow and spread. Researchers in Malaysia wanted to know how the numbers of 'endothelial progenitor cells' (EPCs), which play a role in new vessel formation, changed with increasing grades of astrocytoma. EPCs represent a variety of cell types that circulate in the blood and adhere to the inner linings of blood vessels.

The team of scientists examined brain tissue from 22 astrocytoma patients at the Hospital of University Sains Malaysia. They found that the numbers of endothelial progenitor cells were higher in the tumours than they were in surrounding healthy tissue. They also found that the numbers of these cells inside tumour tissue increased with age and higher tumour grade.

Previous research has shown that patients with grades III and IV astrocytomas who underwent radiotherapy or chemotherapy demonstrated a reduction in the numbers of circulating EPCs. People with grades III and IV astocytomas who didn't undergo treatment had higher numbers of circulating EPCs than healthy people.

Other studies have also shown that significantly reducing EPCs led to impaired and delayed growth in tumours followed by a reduction in the numbers of blood vessels feeding them.

The researchers conclude that their findings suggest that drugs targeting new blood vessel formation given in appropriate doses according to age and tumour grade could prevent astrocytoma growth.

For more information, contact
Priscilla Das
School of Medical Sciences,
Universiti Sains Malaysia
Email: [email protected]; [email protected]

About Pertanika Journal of Science & Technology (JST)
Pertanika Journal of Science & Technology (JST) is published by Universiti Putra Malaysia in English and is open to authors around the world regardless of nationality. Currently, it is published twice a year in January and July. Other Pertanika series include Pertanika Journal of Tropical Agricultural Science (JTAS), and Pertanika Journal of Social Sciences & Humanities (JSSH). Website: http://www.pertanika.upm.edu.my/

Pertanika Journal of Science & Technology aims to provide a forum for high quality research related to science and engineering research. Areas relevant to the scope of the journal include: bioinformatics, bioscience, biotechnology and bio-molecular sciences, chemistry, computer science, ecology, engineering, engineering design, environmental control and management, mathematics and statistics, medicine and health sciences, nanotechnology, physics, safety and emergency management, and related fields of study.

Research paper: https://bit.ly/2trEA3N

For more information about the journal, contact:
The Chief Executive Editor (UPM Journals)
Office of the Deputy Vice Chancellor (R&I)
IDEA Tower 2, UPM-MDTC Technology Centre
Universiti Putra Malaysia
43400 Serdang, Selangor
Malaysia.
Phone: +603 8947 1622 | +6016 217 4050
Email: [email protected]

Distributed for Pertanika Journal of Science & Technology by ResearchSEA.


June 20, 2018 10:00 HKT/SGT
Topic: Research and development
Sectors: Nanotechnology, BioTech, HealthCare
http://www.acnnewswire.com
From the Asia Corporate News Network


Copyright © 2019 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.


Multimedia
A type of highly malignant brain tumour contains a large number of cells involved in the formation of new blood vessels, helping it proliferate and spread. (Copyright: Juan Gaertner via 123rf)
View Image
 

Pertanika Journal
Dec 14, 2018 00:00 HKT/SGT
How to get the most fuel out of microalgae?
Dec 5, 2018 22:00 HKT/SGT
Better aquaculture management rewards Malaysia's fish farmers
Nov 27, 2018 08:00 HKT/SGT
Looking for ways to measure tumour aggression
Oct 2, 2018 19:30 HKT/SGT
Malaysian medicinal herb has anti-diabetic properties
Sept 25, 2018 19:00 HKT/SGT
Trees' species and age affect carbon emissions
Sept 5, 2018 18:00 HKT/SGT
Protecting rice plants by exploiting their natural defences
Aug 13, 2018 18:00 HKT/SGT
Too hot for rice?
Aug 2, 2018 23:00 HKT/SGT
Indonesian Sufism rejects radical Islam
Aug 1, 2018 09:00 HKT/SGT
Anti-ulcer benefits of honey investigated
Feb 19, 2018 23:00 HKT/SGT
Tracking Ocean Salinity from Space using Colour
More news >>
 News Alerts
Copyright © 2019 ACN Newswire - Asia Corporate News Network
Home | About us | Services | Partners | Events | Login | Contact us | Privacy Policy | Terms of Use | RSS
US: +1 800 291 0906 | Beijing: +86 400 879 3881 | Hong Kong: +852 2217 2912 | Singapore: +65 6304 8926 | Tokyo: +81 3 6859 8575

Connect With us: