Top Page | English | 简体中文 | 繁體中文 | 한국어 | 日本語
Tuesday, 4 April 2023, 17:00 HKT/SGT
Share:
    

Source: BioMed X Institute
BioMed X and Merck Expand Collaboration Aiming to Leverage Cancer-Specific Vulnerabilities for Targeted Therapies
After successfully completing a project in RNA splicing in cancer this January, BioMed X and Merck continue their oncology collaboration to explore tumor immunogenicity enhancers.

HEIDELBERG, Germany, Apr 4, 2023 - (ACN Newswire) - BioMed X, an independent biomedical research institute, announces the start of its new research project - "New Strategies to Enhance the Immunogenicity of Tumors" - in collaboration with Merck. The focus of this new research group will be to develop novel approaches for enhancing tumor immunogenicity to broaden the population of patients who could benefit from cancer immunotherapy.


"What if we could overcome the immunosuppressive microenvironment of solid tumors with a novel targeted approach?" asks Dr. Christian Tidona, Founder and Managing Director of the BioMed X Institute. "This call for application is inviting original research proposals that explore new ways to enhance the immunogenicity of tumors and thus boost the efficacy of immune checkpoint inhibitors," explains Dr. Tidona.

A high mutational burden, as well as aberrant mRNA splicing, are sources of neoantigens: unique antigens presented by tumor cells capable of eliciting an effective anti-tumor immune response. The most recently completed BioMed X project was also a Merck collaboration investigating RNA splicing patterns in cancer. "Using a new bioinformatic approach, we were able to query splicing variants that are unique to certain cancers," said Dr. Alexandra Duarte, former group leader at the BioMed X Institute. "Such splicing abnormalities can shape the complex pathophysiology of cancer cells, including through the expression of immunogenic neoantigens," added Dr. Duarte, now a Senior Scientist in the Department of mRNA Cancer Immunotherapies of Prof. Dr. Ugur Sahin at HI-TRON in Mainz, Germany.

The new project launched today, marking the tenth joint research group between the two partners, expands this line of research by targeting tumor-specific DNA Damage Repair (DDR) mechanisms or exploiting tumor-intrinsic DDR defects to increase the tumor mutational burden and immunogenicity. Researchers who are interested in becoming part of this new BioMed X research team in Heidelberg are invited to respond to this international call for application by submitting a project proposal via the BioMed X Career Space at https://career.bio.mx/call/2023-BMX-C01 before May 28, 2023.

About BioMed X

BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany, with a worldwide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world's brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds - academia and industry - and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

Contact Information
Flavia-Bianca Cristian
Recruiting & Communications Manager
fbc@bio.mx
+49 6221 426 11 706

SOURCE: BioMed X Institute


Topic: Business Tieup
Source: BioMed X Institute

Sectors: BioTech, Healthcare & Pharm
http://www.acnnewswire.com
From the Asia Corporate News Network


Copyright © 2024 ACN Newswire. All rights reserved. A division of Asia Corporate News Network.



BioMed X Institute
May 28, 2024 18:00 HKT/SGT
BioMed X Institute and Boehringer Ingelheim Successfully Complete Schizophrenia Research Project
May 16, 2024 22:00 HKT/SGT
New XSeed Labs Research Team Starts Activity in the U.S. in Collaboration With Boehringer Ingelheim
Apr 30, 2024 17:00 HKT/SGT
New Immuno-Oncology Research Project in Partnership With Merck Starts at the BioMed X Institute in Heidelberg
Feb 6, 2024 23:00 HKT/SGT
New T-FINDER Platform Provides Deep Insights Into T Cell Responses Against Novel Cancer Vaccine
Dec 22, 2023 09:00 HKT/SGT
BioMed X Institute and Ono Pharmaceutical Launch New Collaboration in Cancer Research
Nov 7, 2023 19:00 HKT/SGT
BioMed X Launches a New Call for Application in Autoimmune Disease Research
Nov 1, 2023 07:00 HKT/SGT
BioMed X and AbbVie Start New Research Project in the USA
June 29, 2023 17:00 HKT/SGT
BioMed X Institute Starts Its First Research Project With Sanofi on Artificial Intelligence for Drug Development
Apr 27, 2023 20:00 HKT/SGT
BioMed X Launches XSeed Labs in the US with Boehringer Ingelheim - a New Model for Building an External Innovation Ecosystem on an Industry Campus
More news >>
 News Alerts
Copyright © 2024 ACN Newswire - Asia Corporate News Network
Home | About us | Services | Partners | Events | Login | Contact us | Privacy Policy | Terms of Use | RSS
US: +1 214 890 4418 | China: +86 181 2376 3721 | Hong Kong: +852 8192 4922 | Singapore: +65 6549 7068 | Tokyo: +81 3 6859 8575

Connect With us: